9 Health Issues That Arthritis Can Cause

Heart disease and stroke

People with RA have about double the heart-disease risk as their same-age peers.

“Rheumatoid arthritis is considered equal to other [heart-disease] risk factors, such as diabetes, hypertension, increased lipids, smoking, and family history,” Dr. Fiocco says. “It’s at least as important as the other risk factors for premature heart disease and stroke.”

What to do: RA-related inflammation is thought to be the reason why, although some RA medications can contribute to the risk. People with RA should make an extra effort to eat heart-healthy food, manage other risk factors (like avoiding smoking), and monitor cholesterol and blood pressure.

Sjögren’s syndrome

Suddenly in the news because of Venus William’s recently disclosure that she suffers from the condition, Sjögren’s syndrome is an autoimmune disease that attacks the tear and salivary glands, causing dry eyes and mouth. It can arise on its own or as an added complication of rheumatoid arthritis.

What to do:
Unfortunately, there’s no treatment for Sjögren’s, which can lead to vision problems and tooth decay because of the lack of saliva. Moisturizing eye drops, good dental hygiene, and drinking water can help prevent these problems. Prescription drugs such as cevimeline (Evoxac) and pilocarpine (Salagen) can increase the production of saliva and tears. In severe cases, minor surgery can relieve dryness in the eyes.

Non-Hodgkin’s lymphoma

“The one cancer that’s definitely been linked to RA is non-Hodgkin’s lymphoma,” Dr. Fiocco says.

RA patients have a two to four times higher risk than people without RA. Other blood cancers, such as leukemia and other forms of lymphoma, as well as lung cancer and melanoma, may also be a problem. Not only is the disease itself a culprit, but some drugs are too.

In fact, methotrexate (Trexall) and antitumor necrosis factor drugs such as adalimumab (Humira), etanercept (Enbrel), and infliximab (Remicade) carry a warning about increased lymphoma risk. But the benefits may still outweigh the risk, given that the risk is low overall.

What to do: Ensure that you’re getting regular doctor check-ups and ask your doctor what more you can do to stay healthy.

Lung problems

Some 8% of people with RA develop interstitial lung disease, or scarring of the lungs, compared with only 1% to 2% of the general population, says Eric L. Matteson, MD, chair of rheumatology at the Mayo Clinic, in Rochester, Minn.

In addition to the joints, RA can attack the lungs and cause scarring. Over time, this can make breathing difficult. RA treatments such as methotrexate and glucocorticosteroids can increase the risk of interstitial lung disease.

People with RA may also develop inflammation in the lining of the lungs, or pleurisy, which can make breathing painful, and lung nodules, which can be mistaken for cancer.

What to do: If you are having difficulty breathing, talk to a doctor immediately.


RA drugs such as methotrexate, adalimumab (Humira), etanercept (Enbrel), and infliximab (Remicade) suppress the immune system, boosting the risk of infection. That’s on top of an already-increased risk due to the disease itself. “Just having rheumatoid arthritis approximately doubles your infection risk independent of treatment,” says Dr. Matteson.

One risk is tuberculosis (TB), although it is less common in the U.S. than in developing nations.

What to do: Doctors routinely perform a skin test to check for TB before starting a person on immune-suppressing drugs, Dr. Fiocco says. If the test is positive, the doctor will treat the infection first.


Not surprisingly, depression affects more people with RA—perhaps up to twice as many—than those who don’t have the condition. Having to cope with RA in addition to functional disability, loss of independence, and decrease in quality-of-life all contribute to depression, Dr. Fiocco says.

What to do: One small study showed that only 1 in 5 RA patients talk to their doctor about depression. If you have symptoms of depression, get help. According to Dr. Fiocco, with the newer [RA] medications, a lot more quality of life is being maintained these days.


RA can lead to anemia, which is a lack of red blood cells needed to transport oxygen in the body. RA inflammation can suppress the bone marrow that generates red blood cells.

“Anemia is directly related to the activity of the disease,” says Dr. Fiocco. “High levels of inflammation lead to greater degrees of anemia and these are closely correlated. Medication can also exacerbate the problem.”

What to do: If the anemia is due to inflammation, getting it under control will help, Dr. Matteson says. Drugs that spur red-blood-cell production can help too. And if you’re iron deficient, consider iron supplements, but keep in mind that highly active RA can inhibit iron absorption.

Gastrointestinal bleeding

Another RA complication is gastrointestinal problems, primarily bleeding in the digestive tract and ulcers. This can be due to nonsteroidal anti-inflammatory drugs (NSAIDs), now available both over-the-counter (Advil or Aleve) and by prescription (Celebrex).

“The combination of NSAIDs plus steroids makes it even worse,” Dr. Fiocco says. GI bleeding can also cause or worsen anemia. If you’re taking a prescription NSAID, you should be monitored for this side effect.

What to do: If you’re taking an over-the-counter NSAID, stick to the recommended dosage and don’t take more than one NSAID, including aspirin, at a time.