Risk Of AIDS Higher With Hep B Infection
HIV-positive members of the US military starting antiretroviral therapy (ART) with chronic or resolved hepatitis B virus (HBV) infection had a higher risk of AIDS or death than did cohort members without HBV. In contrast, people with chronic HBV gained CD4 cells faster after starting ART than did people without HBV.
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Although HBV coinfection is common with HIV infection because the two viruses share transmission routes, much remains unknown about the potential impact of HBV on clinical outcomes in antiretroviral-treated people. To address that question, the Infectious Disease Clinical Research Program HIV Working Group analyzed ART responses in members of the US Military HIV Natural History Study.