Dementia Linked To Prostate Cancer ADT Treatment
Androgen deprivation therapy (ADT) for prostate cancer (PCa) is associated with an increased risk of dementia, according to a new study.
Using an informatics approach, Kevin T. Nead, MD, MPhil, of the University of Pennsylvania Perelman School of Medicine in Philadelphia, and colleagues examined ADT use and new-onset dementia in a cohort of 9272 men (average age 66.9) with PCa identified via computer-based processing of electronic medical records.
The investigators had previously identified a link between ADT and Alzheimer’s disease, so for the current study, they widened their scope to include all forms of dementia, such as senile dementia, vascular dementia, frontotemporal dementia, and Alzheimer dementia. Nearly 20% of patients received ADT.
Analyses revealed a 2.17 times increased risk of dementia among ADT recipients versus non-recipients, according to findings published online ahead of print in JAMA Oncology. The association held even after exclusion of Alzheimer disease patients, who had 2.32 times greater odds.
The relative risk for dementia at 5-years from ADT initiation was 7.9% among ADT recipients compared with just 3.5% in non-recipients. Patients treated with ADT for at least 12 months had the highest absolute increase in…