Cured! First Adult Canadian Woman Cured of Sickle Cell!

(Photo credit: Nelly Alberola/Radio-Canada)

A Canadian woman just set the bar for possibly many more to be healed of sickle cell anemia after becoming the first adult in Canada to be cured of the disease. She has God, the doctors, and her sister to thank after receiving a life-saving stem cell transplant.

Revée Agyepong, 26, of Edmonton was diagnosed with the disease as a toddler and has never known life without it.

“I remember as far back as elementary feeling sickle cell complications and not knowing what it was,” she said.

“I thought that everyone would go out for recess and play, then come back with a terrible headache and body pain, couldn’t breathe…eventually I realized it was just me.”

Stem cell transplant cures children with sickle cell anemia, says Alberta hospital
Sickle cell anemia is a genetic disease in which red blood cells change into a semi-circular shape and block blood vessels. Symptoms vary from patient to patient but it puts every organ in the body at risk.

Agyepong’s disease manifested as chronic bone and joint pain, irregular heartbeat, kidney stones and shortness of breath.

Back in 2015, 33-year-old Iesha Thomas became the first adult to be cured of sickle cell disease with a chemotherapy-free procedure at University of Illinois Hospital & Health Sciences System (UI Health), the University reported. Thomas was one of 12 adult patients cured of sickle cell disease as part of a clinical trial at UI Health that used stem cell transplantation from healthy tissue, matched from a sibling donor.

Findings from phase I/II of the clinical trial are published online in the journal Biology of Blood & Marrow Transplantation.

Agyepong said when she found out about the success of the treatment in pediatric patients, she was at a point where her health was declining and she was running out of treatment options, but doctors told her she was too old to undergo the procedure.

That left her devastated.

According to Alberta Health Services, the older the patient and donor in bone marrow transplants, the greater the health risks which can even result in death.

But Stephanie Amoah, Agyepong’s older sister, said she could no longer watch her sister struggle in constant pain and started to research which other centers were testing the treatment on adult patients.

“My persistence, my sister’s persistence, and they said my dedication to wanting a cure, was enough for them to just say, you know what, she’s going to be the person, let’s do this,” Agyepong told the CBC.

([Sisters] Photo credit: Nelly Alberola/Radio-Canada)

Stephanie Amoah, Revée Agyepong’s older sister, was a 100% donor match. She said she’s happy to have been part of a process that will give her sister a new life.

Amoah was tested and was found to be a 100 percent match for her sister. Daly said the odds of siblings being a perfect match is one in four.

The transplant, which took place at Calgary’s Tom Baker Cancer Centre, involved Agyepong taking drugs to suppress her immune system and doing a course of low-dose radiation. Amoah underwent a process called apheresis that collected her sickle-cell-free stem cells, which were then given to Agyepong.

“Over the past few months, what we’ve seen is that Revée’s sister’s bone marrow has taken over the production of Revée’s red blood cells,” Daly said. “The amount of sickle cell hemoglobin in her bloodstream has decreased almost to zero.”

Today, Agyepong’s blood tests don’t show any signs of the disease, which makes her essentially cured. Amoah said the change she sees…