modifiable, said study author Marco Solmi, MD, Ph.D. With a concise patient clinical history collection, assessment of comorbidity, routine screening for early dyskinetic movements, and choice of second-generation antipsychotics over first-generation, TD risks could be lowered. “
However, no prevention trial has been run to date to test such a preventive approach, which may be the aim of future clinical research to minimize tardive dyskinesia incidence,” Solmi said.
Mood disorder associations seem to refer mostly to first-generation antipsychotic effects used (or used in high doses) in the literature review, the researchers found.
There were fewer comorbidity related risk factors than those related to treatment risk factors, the study authors learned. Concurrent issues such as diabetes, smoking, and use and/or dependence on alcohol, cocaine, or other substances were found to be modifiable risk factors for tardive dyskinesia.
They also suggested smoking cessation interventions should be a part of DRBA prescriptions, as mental health disorders often go hand in hand with tobacco use. The researchers wrote that individuals with mental disorders smoke nearly half of the cigarettes consumed in the United States.
One risk factor related to treatment the investigators found was