the virus, Rosner and her colleagues thought CBD might help prevent inflammation from harming the lungs and other organs in the body.
Instead, lab tests showed that CBD directly inhibited the virus’ ability to replicate, stopping its spread in human cells. Mice treated with CBD for one week were able to suppress COVID-19 infection in their lungs and nasal passages.
“We just wanted to know if CBD would affect the immune system,” Rosner said in a University of Chicago news release. “No one in their right mind would have ever thought that it blocked viral replication, but that’s what it did.”
To see whether CBD has any real-world potential, the research team analyzed data from 1,212 epilepsy patients prescribed Epidiolex.
People taking Epidiolex were 35% to 52% less likely to suffer a COVID-19 infection than an equal number of folks from a control group not prescribed the drug, according to data drawn from the federally funded National COVID Cohort Collaborative.
The findings were published Jan. 20 in the journal Science Advances.
The researchers believe that CBD fights COVID-19 by prompting cells to release interferon, a biochemical that sabotages the ability of viruses to replicate in cells, Rosner adds.
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“We showed that CBD increases the amount of this [interferon] factor, and if you block that factor from acting, you actually counteract the effect of CBD and now the virus can replicate again,” Rosner shares.
CBD doesn’t affect the ability of the coronavirus to enter cells. Rather, it blocks replication of the virus after it’s already entered cells, the researchers report.
What type of CBD treatment will work best?
It’s likely that people will need high blood levels of cannabidiol, a compound derived from marijuana, appears to show promise in blocking replication of the COVID-19 virus and preventing its spread, lab and animal studies show.for this to work, Rosner points out. That’s where the purity, dosage and type of CBD treatment come into play.
“The way CBD is formulated really determines how much can get into the blood,” Rosner notes. “If it’s introduced as an oil, it’s not very water-soluble and often will go to the liver and get metabolized and broken down. You have to make sure there’s enough in the blood for it to be active.” Don’t think you can smoke weed and get enough CBD to protect yourself that way, either. You won’t absorb enough CBD from the smoke, and you’ll also get too much THC, the compound in pot that gets you high, Rosner shares.”We tested THC. It does not work. Furthermore, when we added THC to CBD, it prevented CBD from blocking the replication of the virus,” Rosner notes.
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“This is an early study that needs further confirmation but does provide a pathway for new ways to help combat COVID-19,” Adalja shares. “The more tools that we have, the better we will be. However, further study on CBD delivery mechanisms, CBD concentrations, and ideally administration of CBD in a prospective, randomized trial are needed to further explore this finding and its clinical applicability.”