Top 15 Cities With the Most STDs (2022)

It seems like for the past two years, the only disease that has dominated the news and the one we talk about the most has been COVID.

But after a long, COVID-related delay, the Centers for Disease Control and Prevention (CDC) has finally released its latest Sexually Transmitted Disease (STD) Surveillance Report, and the numbers are disturbing. For the 6th consecutive year, the STD rate in the United States hit a record high.

Before we get to the full rankings, here are some interesting facts and trends that need to be called out:

• Chlamydia, gonorrhea, and syphilis top the list of most commonly reported new STD infections. Taken together, infections from these three reportable diseases increased almost 30% from 2015 to 2019.
• The South continues to be disproportionately represented among the hardest-hit cities. Of the Top 25, 17 are southern cities (or 19, if you use the Census Bureau’s definition to include Baltimore and the District of Columbia).
• Four of the Top 25 cities are located in Florida, which is a worrisome development for the Sunshine State.
• California and Texas tie for the state with the most cities in our rankings, at 14 apiece, though these are after all two of the largest states in our country. Alabama is next with six cities.

You should also know that based on CDC data, STD rates were:

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• 5-8 times higher for African Americans or Black people than for non-Hispanic White people
• 3-5 times higher for American Indians, Native Alaskans, and Native Hawaiians than for non-Hispanic White people
• 1-2 times higher for Hispanic or Latino people than for non-Hispanic white people

Ok, now on to the list:

15. Indianapolis, IN

STD Cases / 100K Population
1,905
HIV Cases
4,736

Chlamydia Cases
10,503

Gonorrhea Cases
4,073

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Syphilis Cases
154

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14. Tallahassee, FL

STD Cases / 100K Population
1,990

HIV Cases
1,257

Chlamydia Cases
3,379

Gonorrhea Cases
1,083

Syphilis Cases
101

13. Milwaukee, WI

STD Cases / 100K Population
2,007

HIV Cases
2,144

Chlamydia Cases
11,703

Gonorrhea Cases
5,083

Syphilis Cases
101

12. Memphis, TN

STD Cases / 100K Population
2,045

HIV Cases
6,601

Chlamydia Cases
11,407

Gonorrhea Cases
4,620

Syphilis Cases
226

11. New Orleans, LA

STD Cases / 100K Population
2,213

HIV Cases
6,911

Chlamydia Cases
8,190

Gonorrhea Cases
3,004

Syphilis Cases
153

10. Fayetteville, NC

STD Cases / 100K Population
2,255

HIV Cases
1,368

Chlamydia Cases
4,337

Gonorrhea Cases
1,741

Syphilis Cases
49

9. Knoxville, TN

STD Cases / 100K Population
2,314

HIV Cases
960

Chlamydia Cases
3,710

Gonorrhea Cases
1,626

Syphilis Cases
34

8. Montgomery, AL

STD Cases / 100K Population
2,365

HIV Cases
1,470

Chlamydia Cases
2,569

Gonorrhea Cases
1,226

Syphilis Cases
75

7. New York, NY

STD Cases / 100K Population
2,544

HIV Cases
97,206

Chlamydia Cases
74,014

Gonorrhea Cases
28,394

Syphilis Cases
1,952

6. Augusta, GA

STD Cases / 100K Population
2,596

HIV Cases
1,400

Chlamydia Cases
2,636

Gonorrhea Cases
1,100

Syphilis Cases
97

5. Washington DC

STD Cases / 100K Population
2,771

HIV Cases
62

Chlamydia Cases
17,589

Gonorrhea Cases
2,236

Syphilis Cases
865

4. Philadelphia, PA

STD Cases / 100K Population
2,827

HIV Cases
16,917

Chlamydia Cases
20,354

Gonorrhea Cases
7,043

Syphilis Cases
470

3. San Francisco, CA

STD Cases / 100K Population
3,150

HIV Cases
12,149

Chlamydia Cases
9,505

Gonorrhea Cases
5,593

Syphilis Cases
579

2. Baltimore, MD

STD Cases / 100K Population
3,707

HIV Cases
9,441

Chlamydia Cases
8,602

Gonorrhea Cases
3,982

Syphilis Cases
312

And the number one STD-infested state is...

1. Jackson, MS

STD Cases / 100K Population
4,281

HIV Cases
2,541

Chlamydia Cases
3,984

Gonorrhea Cases
2,081

Syphilis Cases
100