The anti-inflammatory benefits of a common gout medicine may help save the lives of heart failure patients, researchers say. This could be beneficial for Black Americans, who have a higher risk of gout due to their higher prevalence of risk factors such as obesity, diabetes, chronic kidney disease, and hypertension.
The medication, colchicine, could also reduce the risk of heart attack and stroke in patients whose arteries are clogged with cholesterol, according to the study authors.
How does gout medicine help heart failure?
“The signal for benefit with colchicine in these patients was very impressive, and I expect that these findings will have quite a significant impact on clinical care in heart failure and future research for patients with this condition,” Dr. Kenneth Bilchick said in a University of Virginia (UVA) news release. He’s a professor of cardiovascular medicine there.
For the study, Bilchick and his team analyzed the records of more than 1,000 patients admitted to the university’s Medical Center between March 2011 and February 2020 for worsening heart failure, which occurs when the heart can’t pump enough blood through the body.
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Survival rates were nearly 98% for those who received colchicine for a gout flare, compared with less than 94% for those who weren’t given colchicine.
Many patients with heart failure also have gout, a type of arthritis caused by a buildup of uric acid crystals in the joints.
Common treatments for gout include colchicine, steroids and nonsteroidal anti-inflammatory drugs (NSAIDs), such as aspirin and ibuprofen. However, steroids and NSAIDs are not typically given to heart failure patients because they could worsen heart failure symptoms.
Colchicine may benefit heart failure patients by reducing inflammation in the heart and blood vessels, the researchers suggest.
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While these initial findings need to be confirmed in large studies, the research team say they are promising.
“These results highlight the importance of novel inflammatory mechanisms in heart failure,” Bilchick says.
Heart failure is more than just a failure of the pumping function of the heart, says Dr. Sula Mazimba, a UVA School of Medicine researcher and cardiologist. “There are other processes that are involved, especially during an acute hospitalization phase, such as elevated
