problems like severe anemia, hypoxemia, and stroke because of disturbed blood flow.
Transfusions can help SCD patients avoid the complications that come with surgery. The American Society of Hematology advises blood transfusions for SCD patients who will be sedated for a period of time beyond 1 hour.
What Are the Dangers of Receiving Blood Transfusions if You Have Sickle Cell Disease?
Whether you have SCD or not, there are dangers associated with blood transfusions for everyone. Although you might be concerned about getting a bloodborne illness from your blood donor, this is extremely unlikely.
Blood donations are thoroughly screened. A blood transfusion has a one in two million chance of transmitting HIV and a one in fifty chance of transmitting a form of hepatitis.
Not an infectious condition, but rather your body’s response to the donated blood poses the greater risk for most people. This can appear in various ways:
- An allergic response: These reactions can happen even if you receive the same type of blood.
- Acute immune hemolytic reaction: This is a reaction where your body is shocked by the introduction of donated blood and rejects the transfusion. It can happen that your body will still mount an immune response to donated blood, resulting in an allergic reaction that will require your medical team to stop the transfusion and treat your reaction with antihistamines or other medications. Rare but significant transfusion reactions typically occur when the blood you’re receiving isn’t a perfect match for your blood type. Discuss your risk with a doctor, especially if it has already happened to you.
- Fever: One of the more frequent adverse effects of a transfusion is a fever, which can happen as your body responds to receiving white blood cells. Your immune system identifies these cells as foreign, which prompts an immunological reaction and a fever. Fever might occasionally cause your transfusion to be disrupted.
Although everyone faces these dangers, those with SCD are more vulnerable because of how many transfusions they may need throughout their lifespan.
When your body produces antibodies in reaction to donor blood cells, it is said to have undergone alloimmunization. A third of those with SCD experience it. Alloimmunization can result in a delayed hemolytic transfusion reaction that could be lethal.
RELATED: What Every Sickle Cell Warrior Must Know About Their Patient Journey
What Steps Are Included in a Blood Transfusion for a Sickle Cell Patient?
Knowing your blood type and discussing your transfusion history with a medical team are prerequisites if you require a blood transfusion to treat SCD or its consequences. They need to know if you’ve ever had any adverse reactions and how many blood transfusions you’ve had.
This knowledge can assist a doctor in taking preventative measures against issues like iron overload.
The first stage is a type and screen blood test, which identifies your blood type and compares it to donors’ blood types. A doctor may request a ferritin blood test before your transfusion to monitor your iron levels if you’ve received more than ten transfusions in your lifetime.
Here is what to anticipate as the transfusion begins:
- The medical team will use an intravenous (IV) catheter or another device to enter your blood vessels. For a straightforward blood transfusion, a sizable peripheral IV line put into your arm is typically sufficient. A deeper or more long-lasting access line may be necessary for repeated or frequent transfusions.
- A nurse or doctor will review your medical history, lab results, allergies, and the rationale for the transfusion.
- Before the transfusion starts, your blood will be compared to the donor’s blood and cross-checked against it.
- Vital signs, such as your heart rate, blood pressure, temperature, and other readings, will be gathered by your medical team.
- The transfusion’s volume and rate will be determined by a physician. Simple transfusions might take anything from one to four hours.
- Throughout the blood transfusion, you’ll be constantly watched by a team. Your vital signs will be checked once more as they check for transfusion responses.
- The medical staff will keep an eye on you for a while after the blood transfusion is finished. They would probably take your IV line out if you underwent outpatient surgery to receive blood. After your transfusion, the IV site could be painful for a couple of days.