Acetaminophen, on the other hand, is a medicine that works much like aspirin, but still has a few differences. It also lowers fevers and helps with headaches, like aspirin, but it does not treat the inflammation that can occur with muscle sprains or arthritis. However, acetaminophen is less irritating to the stomach than aspirin, and usually does not cause as many side effects in the digestive tract as aspirin does. Acetaminophen is safer for children and people with bleeding disorders as well.People should be cautioned however, that taking acetaminophen in high doses can damage the liver. Because it is found in many over-the-counter combination products, patients should be extra cautious to make sure that they are not taking above the daily recommended dose (4000 mg per day) without consulting their physician or pharmacist.