As a woman of color who has dedicated my career to elevating the understanding of scientific data in the context of clinical research and care, I have witnessed firsthand how minorities have been historically underrepresented in clinical trials.
My passion stemmed in part, from personal experiences—a life-threatening drug reaction that hospitalized me and took me out of school for a semester, and the sudden loss of my college boyfriend's father to a heart attack at age 44—these pivotal moments made me hyper curious about medications, and equity across sub-populations (e.g. gender, race, age).
The lack of Black Americans in clinical trials
In my roles in the pharmaceutical industry, I engaged with clinician research thought-leaders who told me how new drugs often did not have the same efficacy or safety profiles in their diverse patients compared to the trial data. For example, some medicines, in their experience, had more side effects or needed higher doses to achieve comparable results in diverse patients.
I realized if drugs are primarily tested in white males, comprising roughly 75 percent of trial subjects, that leaves knowledge gaps about how they will perform in women, minority racial/ethnic groups, older adults, and other underrepresented populations. Moreso, it is often these groups who are disproportionately impacted by chronic illnesses like heart disease and diabetes.
How we can improve Black American clinical trial involvement
To increase the amount of Black (and other historically under-represented) Americans in clinical trials, we cannot take a one-size-fits-all approach. Through analyzing health disparities, social determinants of health (SDoH) data, and
collaborating with community partners, we design and build outreach and engagement activations to break down barriers e.g. the lack of awareness about trials, mistrust of research, and logistical obstacles that prevent equitable access across sub-groups.
Digital solutions like decentralized trials, which allow patients to participate remotely, enhance access for some. However, equitable outreach must also bridge digital literacy gaps and use omnichannel tactics pairing high-tech with high-touch, participatory community engagement that establishes and sustains trust.
Related: 6 Myths About Clinical Trials That Are Keeping Us Out of Them
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In modern settings, clinical trials can become as accessible as walking into your local retail pharmacy. Pharmacists are being trained to have clinical trial conversations with consumers and provide real-world evidence on safety and effectiveness reflective of America’s diversity. Then doctors can prescribe treatments to all patients with greater confidence and patients can formulate their perspective of relevance about clinical trials.
My life’s work has shown me health equity is integral for people to live joyful, whole lives achieved through optimal wellness. I want to inspire communities disproportionately impacted by illness to envision better health is possible for them through clinical trial participation advancing medical progress. Representation in research leads to reducing disparities in care. It takes all of us working together across healthcare, industry, academia, and community to achieve health equity. But when we succeed, it unleashes the potential and promise for people to thrive.
Kendal K. Whitlock is the Head of Digital Optimization, RWE Clinical Trials, with Walgreens. This role leverages data assets and partnerships to advance culturally responsive approaches to clinical research. In her role, Ms. Whitlock focuses on digital, educational, and community-based solutions to drive access to clinical trials, enabling opportunities that are flexible and convenient for participants.
