• Skip to main content
  • Skip to secondary menu
  • Skip to primary sidebar
  • Skip to footer
BlackDoctor.org
Where Wellness & Culture Connect

Where Wellness & Culture Connect

  • Conditions
  • Wellness
  • Lifestyle
  • Longevity
  • Clinical Trials
  • Resources
    • Generational Health
    • Top Blacks in Healthcare 2025
    • Hall Of Fame
    • Clinical Trials Resource Center
    • Obesity Resource Center
    • Cancer Resource Center
    • Wellness on the Yard
    • Immunocompromised Care
    • BDO Resource Library
  • Find A Doctor
  • BDO TV
Home / Health Conditions / Clinical Trials / This Clinical Trial Showed Promise in Recurrent Prostate Cancer Patients

This Clinical Trial Showed Promise in Recurrent Prostate Cancer Patients

This Clinical Trial Showed Promise in Recurrent Prostate Cancer Patients

(HealthDay News) — For men with high-risk biochemically recurrent prostate cancer, olaparib monotherapy yields good prostate-specific antigen (PSA) response rates, especially among those with BRCA2, according to a study published online Aug. 22 in JAMA Oncology.

Catherine H. Marshall, M.D., from the Johns Hopkins University School of Medicine in Baltimore, and colleagues examined the activity of olaparib monotherapy among patients with high-risk biochemically recurrent prostate cancer after radical prostatectomy in a phase 2, single-arm nonrandomized controlled trial. A total of 51 male patients were enrolled and received treatment with olaparib twice daily until doubling of baseline PSA, clinical or radiographic progression, or unacceptable side effects.

The researchers found 13 participants (26 percent) had a 50 percent or higher decline in PSA from baseline (PSA50); all were within the homologous recombination repair-positive group (13 of 27; 48 percent). A PSA50 response occurred in all 11 participants with BRCA2 alterations. Fatigue, nausea, and leukopenia were common adverse events (63, 55, and 43 percent, respectively), which were consistent with known adverse effects of olaparib.

You May Also Like
Psoriatic Arthritis Can Feel Beyond Your Control. Consider a Different Direction. Learn More Here. Psoriatic Arthritis Can Feel Beyond Your Control. Consider a Different Direction. Learn More Here.

“Molecularly targeted therapies in select patient populations may be a reasonable treatment strategy for some patients with recurrent prostate cancer, even in the absence of androgen deprivation therapy,” the authors write.

Several authors disclosed ties to pharmaceutical companies, including AstraZeneca, which provided olaparib and financial support for the study.

What does this mean for men with prostate cancer?

This clinical trial is looking at a drug called olaparib from AstraZeneca to treat a type of prostate cancer called biochemically recurrent prostate cancer. This means the cancer has come back after surgery, even though there’s no evidence of it on scans.

You May Also Like
Get GLP-1s Delivered to You As Low As $99/Month! Get GLP-1s Delivered to You As Low As $99/Month!

How does olaparib work?

Olaparib is a type of drug that targets cancer cells. It works by stopping cancer cells from repairing themselves, which can lead to their death.

Who was in the study?

The study included men who had prostate cancer surgery and then experienced a recurrence. They had to have a certain level of a protein called PSA (prostate-specific antigen) in their blood.

What were the results of the trial?

Some men responded well: About half of the men with a specific genetic change called a BRCA2 alteration saw a significant decrease in their PSA levels. This suggests that olaparib might be effective for this group of patients.
Not everyone benefited: Men without the BRCA2 alteration didn’t see as much benefit from olaparib.
Side effects: The study also looked at the side effects of olaparib. Common side effects included fatigue, nausea, and low blood cell count.

The study shows that olaparib might be a promising treatment option for men with biochemically recurrent prostate cancer who have a BRCA2 alteration. However, more research is needed to confirm these findings and to understand how olaparib can be used most effectively in this setting.

What does this mean for Black men?

Black men are disproportionately affected by prostate cancer, and clinical trials like this can help address this disparity. By participating, they contribute to research that can lead to new treatments and improved outcomes. Clinical trials offer the opportunity to receive cutting-edge care and can help raise awareness about prostate cancer. Participating can empower Black men to take a proactive role in their own health and advocate for better health care access for their community.

Abstract/Full Text (subscription or payment may be required)

By Team BlackDoctor.org | Published August 26, 2024

August 26, 2024 by Team BlackDoctor.org

The Latest In Clinical Trials

This Black Dermatologist Wants You to Join a Psoriasis Clinical Trial

This Black Dermatologist Wants You to Join a Psoriasis Clinical Trial

Dr. Chesahna Kindred is a board-certified dermatologist and founder of Kindred Hair & Skin Center in Marriottsville, Maryland. Because dermatological conditions often present differently on melanin-rich skin, the Black patients that Kindred treats often face challenges unaddressed by clinical research read more about This Black Dermatologist Wants You to Join a Psoriasis Clinical Trial
diabetes care

Imagine Easier Diabetes Care — Here’s How You Can Help Make It Real

If you or someone you love is living with diabetes, you already know it’s more than just a condition—it’s a daily commitment. From checking blood sugar and taking medication to planning meals and managing stress, it can feel like a read more about Imagine Easier Diabetes Care — Here’s How You Can Help Make It Real
clinical trial participation

Exclusive Access to Tomorrow’s Treatments—How Clinical Trials Are ‘Opening Doors’

Clinical trials are at the heart of medical innovation. They help researchers test new treatments, improve existing ones, and discover cures for diseases. However, many people, particularly in underserved communities, are unaware of clinical trials or face significant barriers to read more about Exclusive Access to Tomorrow’s Treatments—How Clinical Trials Are ‘Opening Doors’
Understanding Breast Cancer Clinical Trials for Black Women

Understanding Breast Cancer Clinical Trials for Black Women

Breast cancer is a type of cancer that starts with the growth of cells within the breast tissue.  Several types of breast cancer exist, including:  Ductal carcinoma in situ Invasive breast cancer Triple-negative breast cancer Inflammatory breast cancer Paget disease read more about Understanding Breast Cancer Clinical Trials for Black Women
Black Participation in Food Allergy Trials Can Be Life-Saving

Black Participation in Food Allergy Trials Can Be Life-Saving

There's promising new research for food allergies called Food Oral Immunotherapy (FOIT). This treatment enables individuals to gradually reintroduce foods they're allergic to, desensitizing them and reducing their reactions. However, a new study shows a major problem: most research on read more about Black Participation in Food Allergy Trials Can Be Life-Saving
OP-ED: Breast Cancer Clinical Trials Are Missing Black Women

OP-ED: Breast Cancer Clinical Trials Are Missing Black Women

Good news: There’s been an overall decline in breast cancer deaths over the last 30 years. Bad news: Black women have a mortality rate 41 percent higher than that of white women. These differences are multifactorial, but are partly a read more about OP-ED: Breast Cancer Clinical Trials Are Missing Black Women

Primary Sidebar

Subscribe to our newsletter

Icon

A Black Women's Guide To Beating Breast Cancer

1 file(s) 967 KB
Download

Trending Articles

This Black Dermatologist Wants You to Join a Psoriasis Clinical Trial

This Black Dermatologist Wants You to Join a Psoriasis Clinical Trial

Why Black Americans Are Waiting Longer for a Kidney Transplant

kidney transplant

Understanding Breast Cancer Clinical Trials for Black Women

Understanding Breast Cancer Clinical Trials for Black Women

Could Your Diet Be Making Your Chronic Hives Worse?

Could Your Diet Be Making Your Chronic Hives Worse?

Black Participation in Food Allergy Trials Can Be Life-Saving

Black Participation in Food Allergy Trials Can Be Life-Saving
Find a Culturally Sensitive Doctor

Footer

Where Wellness & Culture Connect

BDO is the world’s largest and most comprehensive online health resource specifically targeted to African Americans. BDO understands that the uniqueness of Black culture - our heritage and our traditions - plays a role in our health. BDO gives you access to innovative new approaches to the health information you need in everyday language so you can break through the disparities, gain control and live your life to its fullest.

Connect With Us

Resource Centers

  • Top Blacks in Healthcare
  • Clinical Trials
  • Wellness on the Yard
  • Cancer
  • Immunocompromised Care
  • About Us
  • Privacy Policy
  • Cookie Policy
  • Terms of Service
  • Careers
  • Advertise With Us
  • Advertising & Sponsorship Policy
  • Daily Vitamina
  • TBH

Copyright © 2025, Black Doctor, Inc. All rights reserved.