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Home / Health Conditions / Lupus / Common Signs Of Lupus People Rarely Talk About

Common Signs Of Lupus People Rarely Talk About

common signs of lupus

Lupus is an autoimmune disease that can affect nearly any organ or body part and can last for a prolonged period. Your immune system mistakenly attacks healthy cells, causing pain, swelling, and tissue damage. The Lupus Foundation of America says that about five million people worldwide have lupus, and women are nine times more likely than men to get it. Symptoms and common signs of lupus can come and go, which makes it hard to figure out what’s wrong. You may have flare-ups and then get better. Here we’ll help you recognize some more common signs of lupus.

Common Signs Of Lupus

While fatigue, hair loss, joint pain, and skin rashes are some of the most well-known common signs of lupus, other common signs of lupus should be on your radar.

Vision Loss

The eyes can be affected by lupus. Mutations in the skin of the eyelids, dry eyes, inflammation of the white layer on the outside of the eyeball, changes in the blood vessels in the retina, and nerve damage that affects how the eye moves and how well it sees are all possible.

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The most common eye problem caused by lupus is damage to the blood vessels in the retina. This vision loss ranges from mild to severe. One to two percent of people with lupus may lose their sight quickly because of optic neuropathy.

Raynaud’s Syndrome

Raynaud’s syndrome makes it hard for blood to get to the hands and feet (most commonly the fingers and toes). This could be caused by cold temperatures or stress.

When fingers or toes don’t get enough blood, they turn white, red, blue, or purple. One-third of people with lupus get Raynaud’s, which is usually caused by nerve or blood vessel irritation.

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RELATED: 11 Ways Lupus Can Affect Your Body

Photosensitivity

It has been shown that ultraviolet (UV) rays make the symptoms of 40 to 70 percent of people with lupus worse and cause flare-ups. People with cutaneous and systemic lupus get rashes, fever, fatigue, and joint pain when they are sensitive to light.

The Lupus Foundation of America suggests people with lupus generally spend less time in the sun, but also:

  • Wear clothes that protect them from the sun
  • Apply sunblock with at least 70 SPF
  • Stay out of the sun between 10 a.m. and 4 p.m.

Dry Eyes

Lupus can cause dry eyes, making them itchy, gritty, scratchy, sore, watery, and blurry. Dryness can damage the surface of the eye and make it hard to see.

About 20 percent of people with lupus also have Sjogren’s disease, which means that their tear glands don’t produce enough moisture to keep the eyes moist.

Central Nervous System Affected

Neuropsychiatric lupus (NPSLE), neurocognitive impairment, or central nervous system lupus may be diagnosed (CNS lupus). Lupus can affect almost every part of the body, including the brain and central nervous system (CNS).

When lupus affects the CNS and brain, it can cause headaches, dizziness, fatigue, depression, seizures, strokes, trouble seeing, mood changes, and difficulty focusing. Some lupus drugs could have side effects like CNS lupus, so you should talk to your doctor to find out why.

Cognitive Dysfunction

Up to 50 percent of people with lupus have “brain fog.” The LFA says that people with cognitive impairment may feel lost, tired, forget things, or have trouble putting their thoughts into words. Brain fog can be annoying, but there are ways to deal with it like getting enough sleep, eating a whole food diet, and exercising regularly.

Lung Involvement

Pleuritis, pneumonitis, chronic diffuse interstitial lung disease, and pulmonary emboli are some of the most common lung problems that are linked to lupus (blood clots that block the arteries leading to the lungs). Pleuritis discomfort affects 40 to 60 percent of lupus patients.

The LFA says lupus can hurt the membranes that line the lungs, the blood vessels inside the lungs, and the diaphragm.

RELATED: What You Need to Know About Lupus

Gastrointestinal Problems

Lupus can affect the body’s automatic functions, such as heart rate, blood pressure, body temperature regulation, breathing, and digestion. Lupus affects the GI tract, and GI problems like esophageal disorders (like GERD), digestive problems, inflammatory bowel disease (IBD), peritonitis and ascites, pancreatitis, liver problems, and peptic ulcers are common in people with lupus.

Costochondritis

As previously mentioned, pleuritic chest pain, which is a pain when you breathe, is a common sign of lupus. Costochondritis, an inflammation of the cartilage that connects the rib to the sternum, could be the cause of this kind of chest pain.

It can be very painful, but it’s usually easy to figure out because the pain is usually in the chest wall and stays there.

 

symptoms of lupus

What Is Treatment Like For Lupus?

If you have these common signs of lupus, you’ll likely be recommended a comprehensive lupus treatment that encompasses controlling symptoms, preventing immune system attacks, and protecting organs.

Symptoms determine lupus treatment, so your doctor will discuss the treatment’s advantages and dangers. Your doctor may modify your medicines or doses when your symptoms flare and subside. Lupus drugs include:

  • Nonsteroidal anti-inflammatory drugs (NSAIDs). NSAIDs like naproxen sodium (Aleve) and ibuprofen (Advil, Motrin IB, and others) can be bought over the counter and used to treat lupus-related pain, swelling, and fever.
  • Antimalarial drugs. Medications like hydroxychloroquine (Plaquenil), often used to treat malaria, affect the immune system and help lower the risk of lupus flares.
  • Corticosteroids. Steroids, like methylprednisolone (Medrol), are often given in high doses to treat diseases that affect the kidneys and brain. Corticosteroids like Prednisone and others can reduce the inflammation caused by lupus.
  • Immunosuppressants. In severe cases of lupus, drugs that weaken the immune system may be helpful. Some examples are azathioprine (Imuran, Azasan), mycophenolate (Cellcept), methotrexate (Trexall, Xatmep, and others), cyclosporine (Sandimmune, Neoral, Gengraf), and leflunomide (Arava).
  • Biologics. Some people with lupus can also get their symptoms under control by taking belimumab (Benlysta) through an IV.
  • Rituximab. (Rituxan, Truxima) may help some people who other medicines haven’t helped.

Common Signs of Lupus FAQ: What You Need to Know

What is Lupus?

Lupus is a chronic autoimmune disease where the immune system mistakenly attacks healthy tissue. It can affect many parts of the body, including the skin, joints, kidneys, brain, heart, and lungs. The most common type is systemic lupus erythematosus (SLE).

lupus symptoms in women

What Are the Most Common Signs of Lupus in Women?

Lupus affects women about nine times more often than men, and symptoms can vary. The most common signs of lupus in women include:

  • Extreme fatigue

  • Joint pain and swelling

  • Skin rashes (especially a butterfly-shaped rash across the cheeks and nose)

  • Fever without infection

  • Hair loss

  • Sun sensitivity

  • Mouth or nose ulcers

  • Chest pain when breathing deeply

  • Raynaud’s phenomenon (fingers turning white or blue in the cold)

What Are the Early Signs of Lupus Disease?

Early lupus symptoms can be vague and mimic other illnesses, but it’s helpful to know that the common early warning signs include:

  • Persistent fatigue

  • Low-grade fevers

  • Muscle or joint pain

  • Hair thinning

  • Mild rashes

  • Swollen glands

  • Brain fog (trouble concentrating or remembering)

These early symptoms may come and go or gradually worsen before a formal diagnosis is made.

What Are Lupus Flare-up Symptoms?

A lupus flare refers to a period when symptoms worsen.

  • Increased joint or muscle pain

  • Higher fatigue levels

  • Skin rash or hives

  • Fever

  • Headaches

  • Increased swelling

  • Shortness of breath or chest pain

  • Gastrointestinal discomfort

It’s important to identify personal flare-up triggers, which may include stress, sun exposure, infection, or even certain medications.

What Are the Signs and Symptoms of Systemic Lupus Erythematosus (SLE)?

SLE can affect many organs and systems in the body. Common signs and symptoms include:

  • Inflammation in the joints (arthritis)

  • Kidney problems (lupus nephritis)

  • Neurological issues (seizures, headaches, mood changes)

  • Heart or lung inflammation (pleuritis or pericarditis)

  • Skin manifestations (rashes, lesions)

  • Blood disorders (anemia, low white blood cells, or platelets)

SLE symptoms can range from mild to life-threatening and vary widely between individuals.

common signs of lupus

What Are Common Signs of Lupus in Men?

Lupus in men presents similarly to women, but may involve more severe organ involvement. Symptoms include:

  • Joint pain

  • Fatigue

  • Rashes

  • Chest pain

  • Kidney issues

  • Blood disorders

  • Increased risk of cardiovascular complications

Men are more likely to experience kidney disease and blood-related complications from lupus.

What Are the Symptoms of Childhood Lupus?

Childhood lupus, called pediatric SLE, often has more aggressive symptoms than adult-onset lupus. Signs include:

  • Fever

  • Fatigue

  • Joint pain and swelling

  • Weight loss

  • Facial rash

  • Headaches

  • Mood or behavioral changes

  • Kidney inflammation (common in children)

Children may also experience growth delays and school-related challenges due to fatigue and difficulty concentrating.

How Do Lupus Symptoms Differ From Person to Person?

Lupus is known as “the great imitator” because its symptoms resemble those of many other conditions. Symptoms differ depending on:

  • Age

  • Sex

  • Race/ethnicity (more common and severe in African American, Hispanic, and Asian populations)

  • Organs affected

  • Triggers and co-existing conditions

Some may experience mostly joint symptoms, while others may struggle with kidney issues or neurological symptoms.

What Should You Do If You Think You Have Lupus Symptoms?

Early detection and treatment are key to managing lupus effectively and preventing complications. If you’re experiencing persistent or unusual symptoms, especially if they match those listed above:

  1. Track your symptoms.

  2. Schedule a visit with a healthcare provider, preferably a rheumatologist.

  3. Request a referral for blood tests and further evaluations.

Are There Any Symptoms Specific to a Lupus Diagnosis?

While there is no single test for lupus, a combination of symptoms and lab tests leads to a diagnosis. The American College of Rheumatology lists 11 criteria, and having at least four of them may support a lupus diagnosis. These include:

  • Malar rash

  • Discoid rash

  • Photosensitivity

  • Oral ulcers

  • Arthritis

  • Serositis

  • Kidney disorder

  • Neurological disorder

  • Blood disorder

  • Immunologic disorder

  • Positive ANA (antinuclear antibody)

How Can I Tell If My Lupus Is Flaring Up?

Common signs of a lupus flare include:

  • Feeling more tired than usual

  • Worsening joint pain

  • New rashes or skin sensitivity

  • Low-grade fevers

  • Swelling in hands or feet

  • Brain fog or mood shifts

Keeping a symptom diary and communicating with your doctor can help you identify patterns and manage flares more effectively.

Don’t Ignore the Common Signs of Lupus

Although the symptoms and common signs of lupus can come and go, it is helpful to know what your body is trying to tell you. Paying attention to changes—whether it’s joint pain, skin rashes, fatigue, or something that just feels ‘off’—gives you the power to speak up early and get the care you deserve. The bottom line: don’t ignore your symptoms. The sooner lupus is recognized, the sooner you can take steps to manage it and protect your health.

By Dominique Lambright | Published June 16, 2025

June 16, 2025 by Dominique Lambright

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