This Peyronie’s Treatment Skips Surgery, Here’s How It Works

For men facing the physical and psychological toll of Peyronie’s disease, the path to recovery has historically felt like a high-stakes gamble: choose the dramatic results of surgery at the risk of losing penile length, or opt for less invasive methods with uncertain outcomes.

However, a new study published in The Journal of Urology suggests there is a compelling middle ground. Researchers have found that a “triple-threat” non-surgical protocol—combining collagenase Clostridium histolyticum injections, RestoreX penile traction therapy, and sildenafil—offers a powerful alternative to the scalpel.

While surgery remains the gold standard for achieving the straightest possible correction, this non-surgical combination is winning the “quality of life” battle. According to the trial, men utilizing the injection and traction therapy reported significantly higher satisfaction rates, fewer side effects, and, crucially, an increase in penile length—a stark contrast to the slight shortening often associated with surgical correction.

For your Peyronie’s treatment, these new findings could be beneficial if improving sensation and length are as important as correcting the curvature.

What the Study Shows

The study, led by Benjamin Green and Dr. Landon Trost, shows that while surgery “won” on the degree of straightening, the non-surgical protocol outperformed it in almost every category related to the patient’s physical experience and recovery.

1. The “Satisfaction Gap”

Surprisingly, the study found that men in the non-surgical group were significantly happier with their results.

Non-Surgical Group: 50 percent reported being “very satisfied.”
Surgical Group: Only 21 percent reported being “very satisfied.”
Subjective Improvement: 100 percent of the non-surgical group noted better erectile function subjectively, compared to 68 percent in the surgical group.

2. The Battle for Penile Length

One of the most common complaints following Peyronie’s surgery is the loss of length. The study quantified this trade-off clearly:

The Non-Surgical “Triple Threat”: Resulted in a gain of approximately 1.0 cm.
Surgery: Resulted in a loss of approximately 0.5 cm.
Perception: 88 percent of men in the non-surgical group felt their length had improved, while only 16 percent of surgical patients felt the same.

3. Anatomical Correction vs. Adverse Events

The study confirmed that surgery remains the most powerful tool for physically straightening the curve, but it comes at a higher biological cost.

Curvature Improvement: Surgery achieved an 84 percent improvement, while the non-surgical protocol achieved 54 percent.
Safety Profile: The surgical group experienced 50 adverse events, whereas the non-surgical group experienced only 13.
Sensation: 75 percent of the non-surgical group reported absolutely no change in penile sensation, compared to only 11% of the surgical group who remained unchanged.

4. Erectile Function (IIEF)

While subjective reports favored the non-surgical group, the objective data from the International Index of Erectile Function (IIEF) showed that both groups saw similar modest gains:

Non-Surgical: +1.5 point increase.
Surgical: +2.5 point increase.

Which Path Is Right for You?

So how do you know which path is right for you? Here’s a guide to help you make the appropriate decision for personalized care. Reminder, you should always weigh your options with a medical professional.

Choose the Non-Surgical “Triple Threat” Protocol if:

Length is a Priority: You are concerned about the shortening that often accompanies PD and want a chance to actually gain length ($+1.0$ cm in the study).
Sensation is Key: You want to minimize the risk of nerve changes or numbness (75 percent of this group saw zero change in sensation).
Risk Aversion: You prefer a lower rate of adverse events (13 vs. 50 events in the study).
“Good Enough” Straightness: You are satisfied with a significant reduction in curve (54 percent) rather than aiming for a perfectly straight result.

Choose the Surgical Route if:

Maximum Correction is Mandatory: You have a severe curve that makes intercourse impossible, and your primary goal is the straightest possible result (84 percent improvement).
Speed of Result: You prefer a one-time definitive procedure over the multiple cycles and daily traction required for the non-surgical protocol.
Acceptance of Trade-offs: You are willing to sacrifice a small amount of length ($−0.5$ cm) and accept a higher risk of temporary sensation changes to achieve a straight anatomy.

What is the Right Time to Seek Medical Help?

If you notice any of the following symptoms, you should seek medical care, Miami Robotic Surgery notes.

Penile Curvature or a bent penis can be a significant sign of Peyronie’s disease. If you have a noticeable bend in your penis when erect, it can indicate Peyronie’s disease.
Painful erections or intercourse can be a significant symptom. This discomfort and pain can worsen with time.
Erectile dysfunction can develop due to plaque buildup within the penile tissues.
A lump or hard spot in the penis can be the first sign that scar tissue is developing.
Shortening of the Penis can be an indication of the progression of the disease.

A doctor can help you determine the most effective treatment.

By Jason Henderson, BDO Staff Writer | Published February 5, 2026