Black Men Get Better Outcomes From Radiation Rx for Prostate Cancer

A new analysis uncovers a racial paradox in prostate cancer care: While Black men are often diagnosed later and with more aggressive disease than white men, radiation therapy seems to work better for them than for their white peers.

To come to that conclusion, researchers reviewed seven trials comprising more than 8,800 men with prostate cancer. Of these, 1,630 men were Black. Black men were younger than white men (68 versus 71, respectively) and had more advanced disease when they enrolled in these trials. All men received either standard or high-dose radiation therapy, and some also underwent hormonal treatments for the disease.

When compared with white men, Black men were 12% less likely to experience a recurrence of prostate cancer and 28% less likely to have their cancer spread to other organs or to die from prostate cancer after slightly more than 10 years of follow-up.

Bridging the racial gap

Calling the findings "unexpected," study author Dr. Amar Kishan says that access to care may play a role in the historically poor prostate cancer outcomes seen among Black men.

"When Black men with prostate cancer get the same standard of care treatment and are followed the same way as white patients, the survival differences at the very least go away and may even flip," says Kishan, who is vice-chair of Clinical and Translational Research in the Department of Radiation Oncology and chief of Genitourinary Oncology Service at the University of California, Los Angeles.

It's also possible there is something about prostate cancer in some Black men that makes the cancer cells more sensitive to the effects of radiation therapy, Kishan notes. "The results would be at least the same if the major problem was a barrier to care, but we don't have an explanation for the fact that outcomes were better yet."

Importantly, some of the trials included in the new review dated back to the 1980s. "These trials did not necessarily use cutting-edge radiation technology, which means that results may be even better with newer technology," Kishan adds.

The study was published Dec. 29 in the journal JAMA Network Open.

"These data tell us if Black men have access to equitable care, we wouldn't see inferior outcomes as we see today in Black men with prostate cancer compared to white men," says Dr. Neeraj Agarwal, senior director for Clinical Research Innovation at the Huntsman Cancer Institute at the University of Utah in Salt Lake City.

"The biggest question is how to make sure Black men have access to equitable access to health care," Agarwal, who co-wrote an editorial accompanying the new study adds.

"Black men with prostate cancer get less than optimal therapy," Dr. Otis Brawley, a professor of oncology at the Johns Hopkins University School of Medicine in Baltimore notes.

It's not about the color of skin or race, Brawley adds. "Black people are not biologically different than white people," he says. "Race is a socioeconomic category."

Many Black men live in poorer neighborhoods and have less access to high-quality care, Brawley explains.

Another cancer expert says more research is needed to interpret the findings.

"We have seen that the effect of race/ethnicity on treatment outcome can largely be abrogated if patients are diagnosed early and treated appropriately," Dr. Madhur Garg, clinical director of radiation oncology at Montefiore Health System in New York City notes. "Clinical trial enrollment should be encouraged, to learn more about the biology of prostate cancer and whether certain treatments will be more effective than others based on race and ethnicity."

How does radiation therapy work?

The main types of radiation therapy used for prostate cancer are:

External beam radiation
Brachytherapy (internal radiation)

According to the American Cancer Society, radiation therapy uses high-energy rays or particles to kill cancer cells. Depending on the stage of your prostate cancer and other factors, radiation therapy might be used:

As the first treatment for cancer that is still just in the prostate gland and is low grade. Cure rates for men with these types of cancers are about the same as those for men treated with radical prostatectomy.
As part of the first treatment (along with hormone therapy) for cancers that have grown outside the prostate gland and into nearby tissues.
If the cancer is not removed completely or comes back (recurs) in the area of the prostate after surgery.
If the cancer is advanced, to help keep the cancer under control for as long as possible and to help prevent or relieve symptoms.

While you may feel that you must make a decision quickly, it’s important to give yourself time to absorb the information you have just learned, go over it with your doctor and ask questions if there is anything you are unsure about. Choosing the right treatment is key to ensuring that you have a positive outcome.